abstract：RATIONALE:The involvement of glutamate in fear extinction is perhaps the most promising in terms of facilitating clinical interventions for posttraumatic stress disorder (PTSD). This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction. OBJECTIVE:We in...

journal_title：Psychopharmacology

authors： Wu IT,Tang TH,Ko MC,Chiu CY,Lu KT

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:The antidepressant action of acute nicotine administration in clinical and animal studies is well recognized. But the underlying mechanism for this effect has not been carefully discovered. OBJECTIVES:We attempted to evaluate the possible role of N-Methyl-D-aspartate (NMDA) receptors in the antidepressant-li...

journal_title：Psychopharmacology

authors： Haj-Mirzaian A,Kordjazy N,Haj-Mirzaian A,Ostadhadi S,Ghasemi M,Amiri S,Faizi M,Dehpour A

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:Toluene is a misused inhalant with hallucinogenic properties and complex effects. Toluene blocks N-methyl-D-aspartate (NMDA) receptors, releases dopamine (DA), and modifies several neurotransmitter levels; nonetheless, the mechanism by which it produces hallucinations is not well characterized. OBJECTIVES:Th...

journal_title：Psychopharmacology

authors： Rivera-García MT,López-Rubalcava C,Cruz SL

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:The aversive effects of ∆(9)-tetrahydrocannabinol (THC) are mediated by activity at the kappa opioid receptor (KOR) as assessed in adult animals; however, no studies have assessed KOR involvement in the aversive effects of THC in adolescents. Given that adolescents have been reported to be insensitive to the ...

journal_title：Psychopharmacology

authors： Flax SM,Wakeford AG,Cheng K,Rice KC,Riley AL

更新日期：2015-09-01 00:00:00

abstract：RATIONALE:The P3 is a ubiquitous component of stimulus-driven neural activity that can be observed in scalp electrophysiological recordings. Multiple lines of evidence suggest an important role for the noradrenergic system in the generation of the P3. However, pharmacological studies of the P3 using noradrenergic manip...

journal_title：Psychopharmacology

authors： de Rover M,Brown SB,Band GP,Giltay EJ,van Noorden MS,van der Wee NJ,Nieuwenhuis S

更新日期：2015-09-01 00:00:00

abstract：RATIONALE:Obsessive-compulsive disorder (OCD) gradually emerges and reaches clinical significance during early adulthood. Whether a predisposition for OCD manifests as binge eating disorder earlier during adolescence is proposed. OBJECTIVES:To further characterize how OCD-like behaviors increase across maturation and ...

journal_title：Psychopharmacology

authors： Freund N,Thompson BS,Norman KJ,Einhorn P,Andersen SL

更新日期：2015-09-01 00:00:00

abstract：RATIONALE:Successive negative contrast (SNC) describes a change in the behaviour of an animal following a downshift in the quantitative or qualitative value of an expected reward. This behavioural response has been hypothesised to be linked to affective state, with negative states associated with larger and/or prolonge...

journal_title：Psychopharmacology

authors： Phelps CE,Mitchell EN,Nutt DJ,Marston HM,Robinson ES

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Disrupted social behavior, including occasional aggressive outbursts, is characteristic of withdrawal from long-term alcohol (EtOH) use. Heavy EtOH use and exaggerated responses during withdrawal may be treated using glutamatergic N-methyl-D-aspartate receptor (NMDAR) antagonists. OBJECTIVES:The current expe...

journal_title：Psychopharmacology

authors： Hwa LS,Nathanson AJ,Shimamoto A,Tayeh JK,Wilens AR,Holly EN,Newman EL,DeBold JF,Miczek KA

更新日期：2015-08-01 00:00:00

abstract：RATIONALE/OBJECTIVES:The impact of raising glycaemia by ingestion of a glucose drink has revealed cognitive facilitation, particularly for memory and attention. This study aimed to extend current knowledge by examining, for the first time, whether glucose load also moderates task-related (TRT) and task-unrelated though...

journal_title：Psychopharmacology

authors： Birnie LH,Smallwood J,Reay J,Riby LM

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...

journal_title：Psychopharmacology

authors： Larrauri JA,Burke DA,Hall BJ,Levin ED

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Numerous substituted cathinone drugs have appeared in recreational use. This variety is often a response to legal actions; the scheduling of 3,4-methylenedioxypyrovalerone (MDPV; "bath salts") in the USA was followed by the appearance of the closely related drug α-pyrrolidinopentiophenone (alpha-PVP; "flakka"...

journal_title：Psychopharmacology

authors： Aarde SM,Creehan KM,Vandewater SA,Dickerson TJ,Taffe MA

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Catecholamine transmission modulates numerous cognitive and reward-related processes that can subserve more complex functions such as cost/benefit decision making. Dopamine has been shown to play an integral role in decisions involving reward uncertainty, yet there is a paucity of research investigating the c...

journal_title：Psychopharmacology

authors： Montes DR,Stopper CM,Floresco SB

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Like other monoamine releasers such as D-amphetamine, chronic treatment with phenmetrazine can attenuate cocaine self-administration in monkeys. OBJECTIVES:The present studies extended this finding to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse. METHODS:In expe...

journal_title：Psychopharmacology

authors： Czoty PW,Tran P,Thomas LN,Martin TJ,Grigg A,Blough BE,Beveridge TJ

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...

journal_title：Psychopharmacology

authors： Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Acute cocaine administration produces an initial rewarding state followed by a dysphoric/anxiogenic "crash." OBJECTIVE:The objective of this study was to determine whether individual differences in the relative value of cocaine's positive and negative effects would account for variations in subsequent drug s...

journal_title：Psychopharmacology

authors： Ettenberg A,Fomenko V,Kaganovsky K,Shelton K,Wenzel JM

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilita...

journal_title：Psychopharmacology

authors： Kiefer F,Kirsch M,Bach P,Hoffmann S,Reinhard I,Jorde A,von der Goltz C,Spanagel R,Mann K,Loeber S,Vollstädt-Klein S

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Synergistic or supra-additive interactions between the anorectics (dex)fenfluramine and phentermine have been reported previously in the rat and in the clinic. Studies with 5-HT2C antagonists and 5-HT2C knockouts have demonstrated dexfenfluramine hypophagia in the rodent to be mediated by actions at the 5-HT2...

journal_title：Psychopharmacology

authors： Grottick AJ,Whelan K,Sanabria EK,Behan DP,Morgan M,Sage C

更新日期：2015-06-01 00:00:00

abstract：RATIONALE:Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularl...

journal_title：Psychopharmacology

authors： Janetsian SS,Linsenbardt DN,Lapish CC

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...

journal_title：Psychopharmacology

authors： Lai SW,Lin CL,Liao KF

更新日期：2015-06-01 00:00:00

abstract：RATIONALE:Direct activation of the cannabinoid CB1 receptor in the dorsolateral periaqueductal gray (dlPAG) inhibits anxiety- and panic-related behaviours in experimental animals. It has remained unclear, however, whether the local endocannabinoid signalling is recruited as a protective mechanism against aversive stimu...

journal_title：Psychopharmacology

authors： Viana TG,Hott SC,Resstel LB,Aguiar DC,Moreira FA

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...

journal_title：Psychopharmacology

authors： Paine TA,O'Hara A,Plaut B,Lowes DC

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...

journal_title：Psychopharmacology

authors： Abreu-Villaça Y,Filgueiras CC,Correa-Santos M,Cavina CC,Naiff VF,Krahe TE,Manhães AC,Ribeiro-Carvalho A

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:Evidence suggesting that the endogenous cannabinoid (eCB) system can be manipulated to facilitate or impair extinction of learned behaviours has important consequences for opiate withdrawal and abstinence. We demonstrated that the fatty acid amide hydrolase (FAAH) inhibitor URB597, which increases eCB levels,...

journal_title：Psychopharmacology

authors： Manwell LA,Mallet PE

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:Intermittent social defeat stress can induce neuroadaptations that promote compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration activates extracellular signal-regulated kinase (ERK). OBJECTIVE:The present experiments examine whether changes in ERK phosphorylation are ...

journal_title：Psychopharmacology

authors： Yap JJ,Chartoff EH,Holly EN,Potter DN,Carlezon WA Jr,Miczek KA

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. MATERIALS AND METHODS:Here, we exa...

journal_title：Psychopharmacology

authors： Cippitelli A,Ayanwuyi LO,Barbier E,Domi E,Lerma-Cabrera JM,Carvajal F,Scuppa G,Li H,Ubaldi M,Heilig M,Roberto M,Ciccocioppo R

更新日期：2015-03-01 00:00:00

abstract：RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...

journal_title：Psychopharmacology

authors： Hassani S,Alipour A,Darvishi Khezri H,Firouzian A,Emami Zeydi A,Gholipour Baradari A,Ghafari R,Habibi WA,Tahmasebi H,Alipour F,Ebrahim Zadeh P

更新日期：2015-03-01 00:00:00

abstract：RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...

journal_title：Psychopharmacology

authors： Cui X,Lefevre E,Turner KM,Coelho CM,Alexander S,Burne TH,Eyles DW

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia. OBJECTIVES:The objective of this study is to determine the effect of intrav...

journal_title：Psychopharmacology

authors： Nottage JF,Stone J,Murray RM,Sumich A,Bramon-Bosch E,Ffytche D,Morrison PD

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:Schedule-induced polydipsia (SIP) is an established model for studying compulsive behaviour in rats. Serotoninergic drugs effectively reduce compulsive drinking on SIP, and high compulsive drinker rats selected by SIP have shown differences in serotoninergic brain activity. However, the specific serotoninergi...

journal_title：Psychopharmacology

authors： Navarro SV,Gutiérrez-Ferre V,Flores P,Moreno M

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...

journal_title：Psychopharmacology

authors： Tran S,Nowicki M,Muraleetharan A,Gerlai R

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:Stress experience during adolescence has been linked to the development of psychiatric disorders in adulthood, many of which are associated with impairments in prefrontal cortex function. OBJECTIVE:The current study was designed to determine the immediate and enduring effects of repeated social stress on a p...

journal_title：Psychopharmacology

authors： Snyder KP,Barry M,Valentino RJ

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:Limited access nicotine self-administration decreases hippocampal neurogenesis, providing a mechanism for the deleterious effects of nicotine on hippocampal neuronal plasticity. However, recent studies have shown that limited access nicotine self-administration does not exhibit key features of nicotine depend...

journal_title：Psychopharmacology

authors： Cohen A,Soleiman MT,Talia R,Koob GF,George O,Mandyam CD

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:Serotonin 5-HT2A and 5-HT2C receptors are thought to be the primary pharmacological mechanisms for serotonin-mediated hallucinogenic drugs, but recently there has been interest in metabotropic glutamate (mGluR2) receptors as contributors to the mechanism of hallucinogens. OBJECTIVE:The present study assesses...

journal_title：Psychopharmacology

authors： Carbonaro TM,Eshleman AJ,Forster MJ,Cheng K,Rice KC,Gatch MB

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：RATIONALE:Opioid antagonism reduces the consumption of palatable foods in humans but the neural substrates implicated in these effects are less well understood. OBJECTIVES:The aim of the present study was to examine the effects of the opioid antagonist, naltrexone, on neural response to rewarding and aversive sight an...

journal_title：Psychopharmacology

authors： Murray E,Brouwer S,McCutcheon R,Harmer CJ,Cowen PJ,McCabe C

更新日期：2014-11-01 00:00:00

abstract：RATIONALE:Although newer interview methods such as Structured Interview Guide for the Montgomery-Asberg Depression Rating Scale (SIGMA; MADRS) with audiotaping and Rater Applied Performance Scale (RAPS) appraisal have been introduced to improve reliability of ratings in antidepressant clinical trials, there is limited ...

journal_title：Psychopharmacology

authors： Khan A,Faucett J,Brown WA

更新日期：2014-11-01 00:00:00

abstract：RATIONALE:The intake of psychostimulant drugs may induce cognitive dysfunction and negative affective-like states, and is associated with increased activity of stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates neuroendocrine, behavioural and autonomic responses to stressors, and might ...

journal_title：Psychopharmacology

authors： Morisot N,Millan MJ,Contarino A

更新日期：2014-10-01 00:00:00

abstract：RATIONALE:Understanding the mechanisms responsible for stress-induced relapse is important for guiding treatment strategies aimed at minimizing the contribution of stress to addiction. Evidence suggests that these mechanisms involve interactions between noradrenergic systems and the neuropeptide corticotropin-releasing...

journal_title：Psychopharmacology

authors： McReynolds JR,Vranjkovic O,Thao M,Baker DA,Makky K,Lim Y,Mantsch JR

更新日期：2014-10-01 00:00:00

abstract：RATIONALE:An important goal of addiction research is to discover neurobiological markers that could predict the severity of addiction and help to determine appropriate treatment. Brain-derived neurotrophic factor (BDNF) and thiobarbituric acid reactive substances (TBARS) are being related to cerebral plasticity and imp...

journal_title：Psychopharmacology

authors： Sordi AO,Pechansky F,Kessler FH,Kapczinski F,Pfaffenseller B,Gubert C,de Aguiar BW,de Magalhães Narvaez JC,Ornell F,von Diemen L

更新日期：2014-10-01 00:00:00

abstract：RATIONALE:New research findings in the field of neuroactive steroids strongly suggest that to understand their role in physiopathology, it is essential to accurately measure their tissue levels. Through his broad chemical expertise and extensive knowledge of steroids, Dr. Robert H. Purdy pioneered structure-activity re...

journal_title：Psychopharmacology

authors： Vallée M

更新日期：2014-09-01 00:00:00